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KMID : 0927720100110040342
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Korean Clinical Diabetes
2010 Volume.11 No. 4 p.342 ~ p.348
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Four Cases of Ketosis-Prone Diabetes Mellitus
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Lee Chan-Woo
Ryu Myeong-Shin
Lee Min-Young
Lee Mi-Jin
Choi Jong-Su
Kang Jun-Goo
Kim Chul-Sik
Lee Seong-Jin
Hong Eun-Gyoung
Kim Doo-Man
Yu Sung-Hoon
Ihm Sung-Hee
Yoo Jae-Myung
Choi Moon-Gi
Yoo Hyung-Joon
Ryu Ohk-Hyun
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Abstract
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Ketosis-prone diabetes (KPD) is a widespread, heterogeneous syndrome characterized by diabetic ketoacidosis (DKA) or unprovoked ketosis without a precipitating cause that is not necessarily associated with the typical phenotype of autoimmune type 1 diabetes. The presence or absence of β-cell autoimmunity and β-cell functional reserve are important for pathophysiology, clinical course, and outcome. Recently, a few classifications were reported that were clinically and etiologically useful for predicting outcomes. The “Aβ” classification system of KPD has proven to be highly accurate and predictive of clinically important outcomes such as glycemic control and insulin dependence. We reviewed four Korean cases of KPD that manifested with DKA, along with a review of the related literature.
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KEYWORD
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Classification, Diabetic ketoacidosis, Insulin therapy
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